internal tandem duplication

基本解释

AIM: FLT3/internal tandem duplication (FLT3/ITD) in transmembrane region is most common in leukemia related FLT3 mutation.
目的：FLT3跨膜区内部串联重复突变是与白血病发生相关的FLT3基因中最常见的突变类型。
FLT3 Internal tandem duplication (ITD) and tyrosine kinase domain (TKD) mutations are seen in 30% of AML patients (pts) and are associated with poor survival.
30%的急性髓系白血病（AML）患者发生FLT3内部串联重复（ITD）和酪氨酸激酶域（TKD）突变，而且生存预后较差。
This study was to explore the clinical significance of FLT3 internal tandem duplication (FLT3/ITD) in acute myeloid leukemia (AML) with chromosome abnormality.
本研究旨在探讨伴有染色体异常急性髓系白血病患者FLT3跨膜区内部串联重复突变检测的临床意义。